Why does it feel so good to laugh? Research shows that humor activities not only regions of the brain associated with perception and language but also the nucleus accumbens, a region that has been linked to happiness and euphoria, this neutral region is a very powerful brain subsystem. Humor helps physicians to understand social behavior better. One’s sense of humor often dictates if, how, and with whom we establish friendships and even long-lasting romantic relationships. Humor also is a universal coping mechanism when faced with all varieties of stress.